PKR-dependent inflammatory signals
R Kang, D Tang - Science signaling, 2012 - science.org
R Kang, D Tang
Science signaling, 2012•science.orgDouble-stranded RNA–dependent protein kinase (PKR) is implicated in inflammation and
immune dysfunction through its regulation of mitogen-activated protein kinases, interferon
regulatory factor 3, nuclear factor κB, apoptosis, and autophagy pathways. A study shows
that PKR is also required for the activation of inflammasomes and the subsequent release of
high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress
kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and …
immune dysfunction through its regulation of mitogen-activated protein kinases, interferon
regulatory factor 3, nuclear factor κB, apoptosis, and autophagy pathways. A study shows
that PKR is also required for the activation of inflammasomes and the subsequent release of
high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress
kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and …
Double-stranded RNA–dependent protein kinase (PKR) is implicated in inflammation and immune dysfunction through its regulation of mitogen-activated protein kinases, interferon regulatory factor 3, nuclear factor κB, apoptosis, and autophagy pathways. A study shows that PKR is also required for the activation of inflammasomes and the subsequent release of high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and PKR and HMGB1 are attractive targets for inflammasome-associated diseases.
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