[HTML][HTML] Signal Transduction in Receptor for Advanced Glycation End Products (RAGE)
V Rai, AY Maldonado, DS Burz, S Reverdatto… - Journal of Biological …, 2012 - ASBMB
The receptor for advanced glycation end products (RAGE) is a multiligand cell surface
macromolecule that plays a central role in the etiology of diabetes complications,
inflammation, and neurodegeneration. The cytoplasmic domain of RAGE (C-terminal RAGE;
ctRAGE) is critical for RAGE-dependent signal transduction. As the most membrane-
proximal event, mDia1 binds to ctRAGE, and it is essential for RAGE ligand-stimulated
phosphorylation of AKT and cell proliferation/migration. We show that ctRAGE contains an …
macromolecule that plays a central role in the etiology of diabetes complications,
inflammation, and neurodegeneration. The cytoplasmic domain of RAGE (C-terminal RAGE;
ctRAGE) is critical for RAGE-dependent signal transduction. As the most membrane-
proximal event, mDia1 binds to ctRAGE, and it is essential for RAGE ligand-stimulated
phosphorylation of AKT and cell proliferation/migration. We show that ctRAGE contains an …