[HTML][HTML] Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42

BI Hudson, AZ Kalea, M del Mar Arriero, E Harja… - Journal of Biological …, 2008 - ASBMB
Cellular migration is a fundamental process linked to diverse pathological states such as
diabetes and its complications, atherosclerosis, inflammation, and cancer. The receptor for
advanced glycation end products (RAGE) is a multiligand cell surface macromolecule which
binds distinct ligands that accumulate in these settings. RAGE-ligand interaction evokes
central changes in key biological properties of cells, including proliferation, generation of
inflammatory mediators, and migration. Although RAGE-dependent signal transduction is …