Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cells
K Lock, J Zhang, J Lu, SH Lee, PR Crocker - Immunobiology, 2004 - Elsevier
Siglecs are sialic acid binding Ig-like lectins mostly expressed in the haemopoietic and
immune systems. Amongst the 11 human siglecs, there are eight proteins highly related to
CD33 which have biochemical features of inhibitory receptors, containing two conserved
tyrosine-based inhibitory motifs. Five of these (CD33/siglec-3,-5,-7,-9 and-10) are expressed
on circulating monocytes. Here we show that monocytes cultured to differentiate into
macrophages using either GM-CSF or M-CSF retained expression of these siglecs and their …
immune systems. Amongst the 11 human siglecs, there are eight proteins highly related to
CD33 which have biochemical features of inhibitory receptors, containing two conserved
tyrosine-based inhibitory motifs. Five of these (CD33/siglec-3,-5,-7,-9 and-10) are expressed
on circulating monocytes. Here we show that monocytes cultured to differentiate into
macrophages using either GM-CSF or M-CSF retained expression of these siglecs and their …