[HTML][HTML] An overview of the serpin superfamily
Genome biology, 2006•Springer
Serpins are a broadly distributed family of protease inhibitors that use a conformational
change to inhibit target enzymes. They are central in controlling many important proteolytic
cascades, including the mammalian coagulation pathways. Serpins are conformationally
labile and many of the disease-linked mutations of serpins result in misfolding or in
pathogenic, inactive polymers.
change to inhibit target enzymes. They are central in controlling many important proteolytic
cascades, including the mammalian coagulation pathways. Serpins are conformationally
labile and many of the disease-linked mutations of serpins result in misfolding or in
pathogenic, inactive polymers.
Abstract
Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers.
Springer