[HTML][HTML] Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway
D Song, LS Li, KJ Heaton-Johnson… - Journal of Biological …, 2013 - ASBMB
Prolyl hydroxylase domain protein 2 (PHD2, also known as Egg Laying Defective Nine
homolog 1) is a key oxygen-sensing protein in metazoans. In an oxygen-dependent manner,
PHD2 site-specifically prolyl hydroxylates the master transcription factor of the hypoxic
response, hypoxia-inducible factor-α (HIF-α), thereby targeting HIF-α for degradation. In this
report we show that the heat shock protein 90 (HSP90) co-chaperones p23 and FKBP38
interact via a conserved Pro-Xaa-Leu-Glu motif (where Xaa= any amino acid) in these …
homolog 1) is a key oxygen-sensing protein in metazoans. In an oxygen-dependent manner,
PHD2 site-specifically prolyl hydroxylates the master transcription factor of the hypoxic
response, hypoxia-inducible factor-α (HIF-α), thereby targeting HIF-α for degradation. In this
report we show that the heat shock protein 90 (HSP90) co-chaperones p23 and FKBP38
interact via a conserved Pro-Xaa-Leu-Glu motif (where Xaa= any amino acid) in these …