Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance
DS Manoach, RL Gollub, ES Benson, MM Searl… - Biological …, 2000 - Elsevier
Background: Working memory (WM) deficits in schizophrenia have been associated with
dorsolateral prefrontal cortex (DLPFC) dysfunction in neuroimaging studies. We previously
found increased DLPFC activation in schizophrenic versus normal subjects during WM
performance. We now have investigated whether schizophrenic subjects recruit different
brain regions, particularly the basal ganglia and thalamus, components of frontostriatal
circuitry thought to mediate WM. Methods: We examined regional brain activation in nine …
dorsolateral prefrontal cortex (DLPFC) dysfunction in neuroimaging studies. We previously
found increased DLPFC activation in schizophrenic versus normal subjects during WM
performance. We now have investigated whether schizophrenic subjects recruit different
brain regions, particularly the basal ganglia and thalamus, components of frontostriatal
circuitry thought to mediate WM. Methods: We examined regional brain activation in nine …