Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI
DS Manoach, DZ Press, V Thangaraj, MM Searl… - Biological …, 1999 - Elsevier
Background: Neuroimaging studies of schizophrenic subjects performing working memory
(WM) tasks have demonstrated a relative hypoactivity of prefrontal cortex compared with
normal subjects. Methods: Using functional magnetic resonance imaging (fMRI), we
compared dorsolateral prefrontal cortex (DLPFC) activation in 12 schizophrenic and 10
normal subjects during rewarded performance of a WM task. Subjects performed a modified
version of the Sternberg Item Recognition Paradigm (SIRP), a continuous performance …
(WM) tasks have demonstrated a relative hypoactivity of prefrontal cortex compared with
normal subjects. Methods: Using functional magnetic resonance imaging (fMRI), we
compared dorsolateral prefrontal cortex (DLPFC) activation in 12 schizophrenic and 10
normal subjects during rewarded performance of a WM task. Subjects performed a modified
version of the Sternberg Item Recognition Paradigm (SIRP), a continuous performance …