[HTML][HTML] Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice
MC Gropler, TE Harris, AM Hall, NE Wolins… - Journal of Biological …, 2009 - ASBMB
Lipin 1 is a bifunctional intracellular protein that regulates fatty acid metabolism in the
nucleus via interactions with DNA-bound transcription factors and at the endoplasmic
reticulum as a phosphatidic acid phosphohydrolase enzyme (PAP-1) to catalyze the
penultimate step in triglyceride synthesis. However, livers of 8-day-old mice lacking lipin 1
(fld mice) exhibited normal PAP-1 activity and a 20-fold increase in triglyceride levels. We
sought to further analyze the hepatic lipid profile of these mice by electrospray ionization …
nucleus via interactions with DNA-bound transcription factors and at the endoplasmic
reticulum as a phosphatidic acid phosphohydrolase enzyme (PAP-1) to catalyze the
penultimate step in triglyceride synthesis. However, livers of 8-day-old mice lacking lipin 1
(fld mice) exhibited normal PAP-1 activity and a 20-fold increase in triglyceride levels. We
sought to further analyze the hepatic lipid profile of these mice by electrospray ionization …