Two genetic hits (more or less) to cancer
AG Knudson - Nature Reviews Cancer, 2001 - nature.com
AG Knudson
Nature Reviews Cancer, 2001•nature.comMost cancers have many chromosomal abnormalities, both in number and in structure,
whereas some show only a single aberration. In the era before molecular biology, cancer
researchers, studying both human and animal cancers, proposed that a small number of
events was needed for carcinogenesis. Evidence from the recent molecular era also
indicates that cancers can arise from small numbers of events that affect common cell birth
and death processes.
whereas some show only a single aberration. In the era before molecular biology, cancer
researchers, studying both human and animal cancers, proposed that a small number of
events was needed for carcinogenesis. Evidence from the recent molecular era also
indicates that cancers can arise from small numbers of events that affect common cell birth
and death processes.
Abstract
Most cancers have many chromosomal abnormalities, both in number and in structure, whereas some show only a single aberration. In the era before molecular biology, cancer researchers, studying both human and animal cancers, proposed that a small number of events was needed for carcinogenesis. Evidence from the recent molecular era also indicates that cancers can arise from small numbers of events that affect common cell birth and death processes.
nature.com