[HTML][HTML] Distinct Roles of the Two Tumor Necrosis Factor (TNF) Receptors in Modulating TNF and Lymphotoxin α Effects (∗)

AE Medvedev, T Espevik, G Ranges… - Journal of Biological …, 1996 - ASBMB
The role for the two tumor necrosis factor (TNF) receptors in discriminating TNF and
lymphotoxin α (LTα) effects has been studied. TNF and LTα were equally mitogenic in Fs4
fibroblasts, which express a high amount of the p55 compared to the p75 TNF receptors
(TNFRs). In contrast, TNF was more potent than LTα in mediating gene regulation and
cytotoxicity in SW480-βGal cells and KYM-1 cells, which have a high p75/p55 TNFR ratio.
Both TNF and LTα showed comparable affinities for the two TNFRs. However, in contrast to …