Collagen-induced arthritis in TNF receptor-1-deficient mice: TNF receptor-2 can modulate arthritis in the absence of TNF receptor-1
Y Tada, A Ho, S Koarada, F Morito, O Ushiyama… - Clinical …, 2001 - Elsevier
TNF is a potent proinflammatory cytokine important for the development of arthritis in human
and animals. We have investigated the roles of TNF receptor-1 (TNFR1) and TNF receptor-2
(TNFR2) in collagen-induced arthritis (CIA) by inducing CIA in mice genetically deficient in
TNFR1. TNFR1−/− mice developed arthritis with similar incidence and severity as TNFR1+/−
littermates, indicating that TNFR1 is redundant for the development of CIA. Anti-type II
collagen (CII) antibody levels and T cell responses to CII did not differ between TNFR1 …
and animals. We have investigated the roles of TNF receptor-1 (TNFR1) and TNF receptor-2
(TNFR2) in collagen-induced arthritis (CIA) by inducing CIA in mice genetically deficient in
TNFR1. TNFR1−/− mice developed arthritis with similar incidence and severity as TNFR1+/−
littermates, indicating that TNFR1 is redundant for the development of CIA. Anti-type II
collagen (CII) antibody levels and T cell responses to CII did not differ between TNFR1 …