[HTML][HTML] Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote …
GX Ruan, A Kazlauskas - Journal of Biological Chemistry, 2013 - ASBMB
Although a high level of lactate is quintessential to both tumors and wound healing, the
manner by which lactate impacts endothelial cells to promote angiogenesis and thereby
create or restore vascular perfusion to growing tissues has not been fully elucidated. Here
we report that lactate activated the PI3K/Akt pathway in primary human endothelial cells.
Furthermore, activating this signaling pathway was required for lactate-stimulated
organization of endothelial cells into tubes and for sprouting of vessels from mouse aortic …
manner by which lactate impacts endothelial cells to promote angiogenesis and thereby
create or restore vascular perfusion to growing tissues has not been fully elucidated. Here
we report that lactate activated the PI3K/Akt pathway in primary human endothelial cells.
Furthermore, activating this signaling pathway was required for lactate-stimulated
organization of endothelial cells into tubes and for sprouting of vessels from mouse aortic …