Cardiolipin stabilized supercomplexes of Saccharomyces cerevisiae respiratory chain
complexes III and IV (ubiquinol: cytochrome c oxidoreductase and cytochrome c oxidase,
respectively), but was not essential for their formation in the inner mitochondrial membrane
because they were found also in a cardiolipin-deficient strain. Reconstitution with cardiolipin
largely restored wild-type stability. The putative interface of complexes III and IV comprises
transmembrane helices of cytochromes b and c 1 and tightly bound cardiolipin. Subunits …