The biosynthesis and functional role of cardiolipin
M Schlame, D Rua, ML Greenberg - Progress in lipid research, 2000 - Elsevier
Cardiolipin is a unique phospholipid with dimeric structure, carrying four acyl groups and
two negative charges. It is exclusively found in bacterial and mitochondrial membranes,
which are designed to generate an electrochemical potential for substrate transport and ATP
synthesis. The name``cardiolipin''alludes to the tissue from which it was first isolated in 1942
[1]. Indeed, cardiolipin is most abundant in mammalian hearts, and commercial preparations
of cardiolipin are derived from heart tissue to this day. However, cardiolipin can be found in …
two negative charges. It is exclusively found in bacterial and mitochondrial membranes,
which are designed to generate an electrochemical potential for substrate transport and ATP
synthesis. The name``cardiolipin''alludes to the tissue from which it was first isolated in 1942
[1]. Indeed, cardiolipin is most abundant in mammalian hearts, and commercial preparations
of cardiolipin are derived from heart tissue to this day. However, cardiolipin can be found in …