[HTML][HTML] Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes
We reported that amyloid β peptide (Aβ 42) activated neutral SMase 2 (nSMase2), thereby
increasing the concentration of the sphingolipid ceramide in astrocytes. Here, we show that
Aβ 42 induced mitochondrial fragmentation in wild-type astrocytes, but not in nSMase2-
deficient cells or astrocytes treated with fumonisin B1 (FB1), an inhibitor of ceramide
synthases. Unexpectedly, ceramide depletion was concurrent with rapid movements of
mitochondria, indicating an unknown function of ceramide for mitochondria. Using …
increasing the concentration of the sphingolipid ceramide in astrocytes. Here, we show that
Aβ 42 induced mitochondrial fragmentation in wild-type astrocytes, but not in nSMase2-
deficient cells or astrocytes treated with fumonisin B1 (FB1), an inhibitor of ceramide
synthases. Unexpectedly, ceramide depletion was concurrent with rapid movements of
mitochondria, indicating an unknown function of ceramide for mitochondria. Using …