In the general framework of metabolic control theory, we describe a method of mathematical
modelling that provides a way of analysing the sensitivity of a metabolic system to
perturbations of the environment or of the internal state of this system. The method can be
applied to any metabolic system, involving for instance conservation relationships, non-
specific external parameters, etc., and leads in particular to a characterization of the control
matrices and to a generalization of the summation and connectivity theorems. In this paper …