Differential loss of striatal projection systems in Huntington's disease: a quantitative immunohistochemical study
YP Deng, RL Albin, JB Penney, AB Young… - Journal of chemical …, 2004 - Elsevier
Prior studies suggest differences exist among striatal projection neuron types in their
vulnerability to Huntington's disease (HD). In the present study, we immunolabeled the fibers
and terminals of the four main types of striatal projection neuron in their target areas for
substance P, enkephalin, or glutamic acid decarboxylase (GAD), and used computer-
assisted image analysis to quantify the abundance of immunolabeled terminals in a large
sample of HD cases ranging from grade 0 to grade 4 [J. Neuropathol. Exp. Neurol. 44 (1985) …
vulnerability to Huntington's disease (HD). In the present study, we immunolabeled the fibers
and terminals of the four main types of striatal projection neuron in their target areas for
substance P, enkephalin, or glutamic acid decarboxylase (GAD), and used computer-
assisted image analysis to quantify the abundance of immunolabeled terminals in a large
sample of HD cases ranging from grade 0 to grade 4 [J. Neuropathol. Exp. Neurol. 44 (1985) …