The hormone/neuropeptide somatostatin (SOM) exerts multiple functions in the central nervous system, the immune system, the hypothalamo‐pituitary axis, the gastrointestinal tract, and the pancreas. Endogenous SOM occurs in 2 biologically active forms, with 14 or 28 amino acids. Five subtypes of SOM reporters have been cloned. SOM is present in human skin. We have investigated the expression of SOM receptors on human dermal normal fibroblasts. Biotinyl‐SOM allowed the visualization of SOM receptors on human dermal fibroblasts. Radioligand binding with (3‐[¹²⁵I]iodotyrosy]¹¹)‐SOM‐14 were performed on these cells and the effect of SOM‐14 on the DNA synthesis by fibroblasts was evaluated by measuring [³H]‐methyl thymidine incorporation. Saturation curve, and Scatchard plot showed a homogeneous class of receptors with a B^max of 0.055±0.023 nM and K_D of 2.0±0.4 nM (values: mean±SEM). Fibroblasts expressed 3,317±1,385 binding sites per cell. Commpetitive displacement experiments showed that SOM‐14 IC₅₀ was 69.3±4.5 nM (mean±SEM), for SOM‐28 33.2±6.0 nM and for octreotide 36.5±3.3 nM. The K_I values calculated from these IC₅₀ were, respectively: 62.4±4.1 nM; 29.9±5.4 nm; 32.9±2.9 nM. We conclude that subtype 2 or 3 SOM receptros is present on human normal dermal fibroblasts. A weak effect of SOM‐14 on DNA synthesis was observed with SOM concentrations of 10^‐7 and 10^‐6 M.