Brain natriuretic peptide is produced both by cardiomyocytes and cells infiltrating the heart in patients with severe heart failure supported by a left ventricular assist …
AH Bruggink, N de Jonge, MFM van Oosterhout… - The Journal of heart and …, 2006 - Elsevier
BACKGROUND: Brain natriuretic peptide (BNP) is a cardiac neurohormone synthesized in
cardiac ventricles as a result of increased wall stress. Left ventricular assist device (LVAD)
support in patients with end-stage heart failure results in reduced wall stress and therefore
may change BNP levels in the heart. METHODS: BNP plasma levels were measured in 17
patients with end-stage HF before LVAD implantation and at 1 week, 1 month, and 3 months
after LVAD support. BNP-messenger RNA (mRNA) expression in cardiac biopsy specimens …
cardiac ventricles as a result of increased wall stress. Left ventricular assist device (LVAD)
support in patients with end-stage heart failure results in reduced wall stress and therefore
may change BNP levels in the heart. METHODS: BNP plasma levels were measured in 17
patients with end-stage HF before LVAD implantation and at 1 week, 1 month, and 3 months
after LVAD support. BNP-messenger RNA (mRNA) expression in cardiac biopsy specimens …