Clinical strategies and animal models for developing senolytic agents
JL Kirkland, T Tchkonia - Experimental gerontology, 2015 - Elsevier
Aging is associated with increasing predisposition to multiple chronic diseases. One
fundamental aging process that is often operative at sites of the pathology underlying
chronic age-related diseases is cellular senescence. Small molecule senolytic agents are
being developed. For successful drug development: 1) appropriate animal models of human
age-related diseases need to be devised. 2) Models have to be made in which it can be
proven that beneficial phenotypic effects are actually caused through clearing senescent …
fundamental aging process that is often operative at sites of the pathology underlying
chronic age-related diseases is cellular senescence. Small molecule senolytic agents are
being developed. For successful drug development: 1) appropriate animal models of human
age-related diseases need to be devised. 2) Models have to be made in which it can be
proven that beneficial phenotypic effects are actually caused through clearing senescent …