[HTML][HTML] Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation …
I Induruwa, M Moroi, A Bonna, JD Malcor… - Journal of Thrombosis …, 2018 - Elsevier
Essentials• Glycoprotein VI (GPVI) binds collagen, starting thrombogenesis, and fibrin,
stabilizing thrombi.• GPVI‐dimers, not monomers, recognize immobilized fibrinogen and
fibrin through their D‐domains.• Collagen, D‐fragment and D‐dimer may share a common or
proximate binding site (s) on GPVI‐dimer.• GPVI‐dimer–fibrin interaction supports
spreading, activation and adhesion involving αIIbβ3. Summary: Background Platelet
collagen receptor Glycoprotein VI (GPVI) binds collagen, initiating thrombogenesis, and …
stabilizing thrombi.• GPVI‐dimers, not monomers, recognize immobilized fibrinogen and
fibrin through their D‐domains.• Collagen, D‐fragment and D‐dimer may share a common or
proximate binding site (s) on GPVI‐dimer.• GPVI‐dimer–fibrin interaction supports
spreading, activation and adhesion involving αIIbβ3. Summary: Background Platelet
collagen receptor Glycoprotein VI (GPVI) binds collagen, initiating thrombogenesis, and …
