Background: Platelets play a central role in hemostasis, in inflammatory diseases such as
atherosclerosis, and during thrombus formation following vascular injury. Thereby, platelets
interact intensively with monocytes and enhance their recruitment to the vascular wall.
Objectives: To investigate the role of the extracellular matrix metalloproteinase inducer
(EMMPRIN) in platelet–monocyte interactions. Methods and Results: Isolated human
monocytes were perfused in vitro over firmly adherent platelets to allow investigation of the …