[HTML][HTML] Platelets and metastasis revisited: a novel fatty link
GP Gupta, J Massagué - The Journal of clinical …, 2004 - Am Soc Clin Investig
The Journal of clinical investigation, 2004•Am Soc Clin Investig
Platelets have long been suspected of having a role in cancer progression and metastasis
that has largely been attributed to platelet-mediated enhancement of tumor cell survival,
extravasation, and angiogenesis. A study in this issue of the JCI suggests that platelet-
derived lysophosphatidic acid is coopted by aggressive breast and ovarian cancer cells as a
tumor cell mitogen and promoter of osteolysis during bone metastasis.
that has largely been attributed to platelet-mediated enhancement of tumor cell survival,
extravasation, and angiogenesis. A study in this issue of the JCI suggests that platelet-
derived lysophosphatidic acid is coopted by aggressive breast and ovarian cancer cells as a
tumor cell mitogen and promoter of osteolysis during bone metastasis.
Platelets have long been suspected of having a role in cancer progression and metastasis that has largely been attributed to platelet-mediated enhancement of tumor cell survival, extravasation, and angiogenesis. A study in this issue of the JCI suggests that platelet-derived lysophosphatidic acid is coopted by aggressive breast and ovarian cancer cells as a tumor cell mitogen and promoter of osteolysis during bone metastasis.
The Journal of Clinical Investigation