[HTML][HTML] Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRγ chain
B Nieswandt, W Bergmeier, V Schulte… - Journal of Biological …, 2000 - ASBMB
Platelet glycoprotein (GP) VI has been proposed as the major collagen receptor for
activation of human platelets. Human GPVI belongs to the immunoglobulin superfamily and
is noncovalently associated with the FcRγ chain that is involved in signaling through the
receptor. In mice, similar mechanisms seem to exist as platelets from FcRγ chain-deficient
mice do not aggregate in response to collagen. However, the activating collagen receptor on
mouse platelets has not been definitively identified. In the current study we examined the …
activation of human platelets. Human GPVI belongs to the immunoglobulin superfamily and
is noncovalently associated with the FcRγ chain that is involved in signaling through the
receptor. In mice, similar mechanisms seem to exist as platelets from FcRγ chain-deficient
mice do not aggregate in response to collagen. However, the activating collagen receptor on
mouse platelets has not been definitively identified. In the current study we examined the …