Summary Background: Glycoprotein (GP) VI is a key receptor for collagen on the platelet
surface. It is a member of the immunoglobulin superfamily and is uniquely expressed on the
surface of platelets, where it is assembled with the immunoreceptor tyrosine activation motif
subunit, FcR‐γ. We have previously reported the generation of a murine model of GPVI
deficiency that revealed profound defects in collagen‐induced platelet aggregation and in
platelet activation following adhesion to collagen. Beyond the hemostasis/thrombosis …