Circulating monocytes recruited to tissues can differentiate into macrophages and adopt
unique gene expression programs in response to environmental cues. We recently
described the regulated expression of several microRNAs (miRNAs) in polarized human
monocyte-derived macrophages (MDMs). Basal expression of these activation-associated
miRNAs was low in monocytes relative to MDMs. As development occurs in the context of
specific cellular environments, we hypothesized that the rate of miRNA accumulation would …