[HTML][HTML] Cellular processing of cone photoreceptor cyclic GMP-gated ion channels: a role for the S4 structural motif
MP Faillace, RO Bernabeu, JI Korenbrot - Journal of Biological Chemistry, 2004 - ASBMB
We examined cellular protein processing and functional expression of photoreceptor cyclic
nucleotidegated (CNG) ion channels. In a mammalian cell line, wild type bovine cone
photoreceptor channel α subunits (bCNGA3) convert from an unglycosylated state, at 90
kDa, to two glycosylated states at 93 and 102 kDa as they transit within the cell to their final
location at the plasma membrane. Glycosylation per se is not required to yield functional
channels, yet it is a milestone that distinguishes sequential steps in channel protein …
nucleotidegated (CNG) ion channels. In a mammalian cell line, wild type bovine cone
photoreceptor channel α subunits (bCNGA3) convert from an unglycosylated state, at 90
kDa, to two glycosylated states at 93 and 102 kDa as they transit within the cell to their final
location at the plasma membrane. Glycosylation per se is not required to yield functional
channels, yet it is a milestone that distinguishes sequential steps in channel protein …