Despite extensive research, no therapeutic interventions have been shown to prevent AKI,
accelerate recovery of AKI, or reduce progression of AKI to CKD in patients. This failure in
translation has led investigators to speculate that the animal models being used do not
predict therapeutic responses in humans. Although this issue continues to be debated, an
important concern that has not been addressed is whether improvements in preclinical study
design can be identified that might also increase the likelihood of translating basic AKI …