MicroRNA-21 is required for local and remote ischemic preconditioning in multiple organ protection against sepsis
P Jia, X Wu, Y Dai, J Teng, Y Fang, J Hu… - Critical care …, 2017 - journals.lww.com
Objective: Sepsis, triggered by microbial infection, is a common and life-threatening
systemic illness, often leads to impaired function of vital organs. Ischemic preconditioning
induced by transient brief episodes of ischemia is a powerful innate mechanism of organ
protection. We have reported that a 15-minute renal ischemic preconditioning substantially
attenuated subsequent renal ischemia-reperfusion injury. Here, we investigate whether a
brief ischemia and reperfusion in kidney can provide protection at local and remote sites …
systemic illness, often leads to impaired function of vital organs. Ischemic preconditioning
induced by transient brief episodes of ischemia is a powerful innate mechanism of organ
protection. We have reported that a 15-minute renal ischemic preconditioning substantially
attenuated subsequent renal ischemia-reperfusion injury. Here, we investigate whether a
brief ischemia and reperfusion in kidney can provide protection at local and remote sites …