[HTML][HTML] Heterotrimeric G proteins: new tricks for an old dog
B Hampoelz, JA Knoblich - Cell, 2004 - cell.com
B Hampoelz, JA Knoblich
Cell, 2004•cell.comHeterotrimeric G proteins are well known for their function in signal transduction downstream
of seven transmembrane receptors. More recently, however, genetic analysis in C. elegans
and in Drosophila has revealed a second, essential function of these molecules in
positioning the mitotic spindle and attaching microtubules to the cell cortex. Five new
publications in Cell (Afshar et al., 2004; Du and Macara, 2004 [this issue of Cell]; Hess et al.,
2004), Developmental Cell (Martin-McCaffrey et al., 2004), and Current Biology …
of seven transmembrane receptors. More recently, however, genetic analysis in C. elegans
and in Drosophila has revealed a second, essential function of these molecules in
positioning the mitotic spindle and attaching microtubules to the cell cortex. Five new
publications in Cell (Afshar et al., 2004; Du and Macara, 2004 [this issue of Cell]; Hess et al.,
2004), Developmental Cell (Martin-McCaffrey et al., 2004), and Current Biology …
Abstract
Heterotrimeric G proteins are well known for their function in signal transduction downstream of seven transmembrane receptors. More recently, however, genetic analysis in C. elegans and in Drosophila has revealed a second, essential function of these molecules in positioning the mitotic spindle and attaching microtubules to the cell cortex. Five new publications in Cell (Afshar et al., 2004; Du and Macara, 2004 [this issue of Cell]; Hess et al., 2004), Developmental Cell (Martin-McCaffrey et al., 2004), and Current Biology (Couwenbergs et al., 2004) show that this function is conserved in vertebrates and—like the classical pathway—involves cycling of G proteins between GDP and GTP bound conformations.
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