[HTML][HTML] Gα12 specifically regulates COX-2 induction by sphingosine 1-phosphate: Role for JNK-dependent ubiquitination and degradation of IκBα
Cyclooxygenase-2 (COX-2) plays a critical role in vasodilatation and local inflammatory
responses during platelet aggregation and thrombosis. Sphingosine 1-phosphate (S1P), a
sphingolipid released from activated platelets, stimulates COX-2 induction and activates G-
protein-coupled receptors coupled to Gα family members. In this study, we investigated
whether Gα 12 family regulates COX-2 induction by S1P and investigated the molecular
basis of this COX-2 regulation. Gene knock-out and chemical inhibitor experiments revealed …
responses during platelet aggregation and thrombosis. Sphingosine 1-phosphate (S1P), a
sphingolipid released from activated platelets, stimulates COX-2 induction and activates G-
protein-coupled receptors coupled to Gα family members. In this study, we investigated
whether Gα 12 family regulates COX-2 induction by S1P and investigated the molecular
basis of this COX-2 regulation. Gene knock-out and chemical inhibitor experiments revealed …