Substance P activates Mas-related G protein–coupled receptors to induce itch
Background Substance P (SP) is linked to itch and inflammation through activation of
receptors on mast cells and sensory neurons. There is increasing evidence that SP functions
through Mas-related G protein–coupled receptors (Mrgprs) in addition to its conventional
receptor, neurokinin-1. Objective Because Mrgprs mediate some aspects of inflammation
that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to
determine whether itch induced by SP can also be mediated by Mrgprs. Methods Genetic …
receptors on mast cells and sensory neurons. There is increasing evidence that SP functions
through Mas-related G protein–coupled receptors (Mrgprs) in addition to its conventional
receptor, neurokinin-1. Objective Because Mrgprs mediate some aspects of inflammation
that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to
determine whether itch induced by SP can also be mediated by Mrgprs. Methods Genetic …