Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus
F Benedetti, L Colloca, E Torre, M Lanotte… - Nature …, 2004 - nature.com
F Benedetti, L Colloca, E Torre, M Lanotte, A Melcarne, M Pesare, B Bergamasco, L Lopiano
Nature neuroscience, 2004•nature.comPlacebo administration is known to affect the brain both in pain and in Parkinson disease.
Here we show that placebo treatment caused reduced activity in single neurons in the
subthalamic nucleus of placebo-responsive Parkinsonian patients. These changes in activity
were tightly correlated with clinical improvement; no decrease in activity occurred when the
clinical placebo response was absent.
Here we show that placebo treatment caused reduced activity in single neurons in the
subthalamic nucleus of placebo-responsive Parkinsonian patients. These changes in activity
were tightly correlated with clinical improvement; no decrease in activity occurred when the
clinical placebo response was absent.
Abstract
Placebo administration is known to affect the brain both in pain and in Parkinson disease. Here we show that placebo treatment caused reduced activity in single neurons in the subthalamic nucleus of placebo-responsive Parkinsonian patients. These changes in activity were tightly correlated with clinical improvement; no decrease in activity occurred when the clinical placebo response was absent.
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