Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes

AL Birkenfeld, GI Shulman - Hepatology, 2014 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD), hepatic insulin resistance, and type 2 diabetes are
all strongly associated and are all reaching epidemic proportions. Whether there is a causal
link between NAFLD and hepatic insulin resistance is controversial. This review will discuss
recent studies in both humans and animal models of NAFLD that have implicated increases
in hepatic diacylglycerol (DAG) content leading to activation of novel protein kinase Cε
(PKCε) resulting in decreased insulin signaling in the pathogenesis of NAFLD-associated …