[HTML][HTML] Targeted disruption of ROCK1 causes insulin resistance in vivo
Insulin signaling is essential for normal glucose homeostasis. Rho-kinase (ROCK) isoforms
have been shown to participate in insulin signaling and glucose metabolism in cultured cell
lines. To investigate the physiological role of ROCK1 in the regulation of whole body
glucose homeostasis and insulin sensitivity in vivo, we studied mice with global disruption of
ROCK1. Here we show that, at 16–18 weeks of age, ROCK1-deficient mice exhibited insulin
resistance, as revealed by the failure of blood glucose levels to decrease after insulin …
have been shown to participate in insulin signaling and glucose metabolism in cultured cell
lines. To investigate the physiological role of ROCK1 in the regulation of whole body
glucose homeostasis and insulin sensitivity in vivo, we studied mice with global disruption of
ROCK1. Here we show that, at 16–18 weeks of age, ROCK1-deficient mice exhibited insulin
resistance, as revealed by the failure of blood glucose levels to decrease after insulin …