Cutting edge: CNS CD11c+ cells from mice with encephalomyelitis polarize Th17 cells and support CD25+ CD4+ T cell-mediated immunosuppression, suggesting …

P Deshpande, IL King, BM Segal - The Journal of Immunology, 2007 - journals.aai.org
P Deshpande, IL King, BM Segal
The Journal of Immunology, 2007journals.aai.org
CD11c+ dendritic cells (DCs) are a prominent component of CNS infiltrates in mice with
experimental autoimmune encephalomyelitis. However, their role in immunopathogenesis is
controversial. In this study, we report that they originate from peripheral hemopoietic cells
and exhibit diverse functions that change during the course of acute disease. CNS DCs
stimulate naive T cells to proliferate and polarize Th 17 responses when harvested shortly
following disease onset but are relatively inefficient APC by the time of peak disability …
Abstract
CD11c+ dendritic cells (DCs) are a prominent component of CNS infiltrates in mice with experimental autoimmune encephalomyelitis. However, their role in immunopathogenesis is controversial. In this study, we report that they originate from peripheral hemopoietic cells and exhibit diverse functions that change during the course of acute disease. CNS DCs stimulate naive T cells to proliferate and polarize Th 17 responses when harvested shortly following disease onset but are relatively inefficient APC by the time of peak disability. Conversely, they can support CD4+ CD25+ T cell-mediated immunosuppression early during experimental autoimmune encephalomyelitis. Such paradoxical functions might reflect dual roles of CNS DCs in promoting local inflammation while setting the stage for remission.
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