Toxin or medication-induced worsening of preexisting peripheral neuropathy is a generally
accepted but not well-studied phenomenon in humans. Drug-induced exacerbation of
Charcot Marie Tooth disease (CMT) neuropathy is a common concern; a list of potential
drugs to avoid is maintained by the CMT Association but with limited direct evidence or
advice on relative risk. An extensive literature search for reported cases of drug effects in
CMT patients found the vast majority concerned excessive vincristine toxicity in patients with …