[HTML][HTML] Cellular redistribution of Rad51 in response to DNA damage
OS Gildemeister, JM Sage, KL Knight - Journal of Biological Chemistry, 2009 - ASBMB
Exposure of cells to DNA-damaging agents results in a rapid increase in the formation of
subnuclear complexes containing Rad51. To date, it has not been determined to what extent
DNA damage-induced cytoplasmic to nuclear transport of Rad51 may contribute to this
process. We have analyzed subcellular fractions of HeLa and HCT116 cells and found a
significant increase in nuclear Rad51 levels following exposure to a modest dose of ionizing
radiation (2 grays). We also observed a DNA damage-induced increase in nuclear Rad51 in …
subnuclear complexes containing Rad51. To date, it has not been determined to what extent
DNA damage-induced cytoplasmic to nuclear transport of Rad51 may contribute to this
process. We have analyzed subcellular fractions of HeLa and HCT116 cells and found a
significant increase in nuclear Rad51 levels following exposure to a modest dose of ionizing
radiation (2 grays). We also observed a DNA damage-induced increase in nuclear Rad51 in …