[HTML][HTML] The Ca2+/calmodulin‐dependent kinase kinase β‐AMP‐activated protein kinase‐α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin …
MB Onselaer, C Oury, RW Hunter, S Eeckhoudt… - Journal of Thrombosis …, 2014 - Elsevier
Background Platelet activation requires sweeping morphologic changes, supported by
contraction and remodeling of the platelet actin cytoskeleton. In various other cell types,
AMP‐activated protein kinase (AMPK) controls the phosphorylation state of cytoskeletal
targets. Objective To determine whether AMPK is activated during platelet aggregation and
contributes to the control of cytoskeletal targets. Results We found that AMPK‐α1 was mainly
activated by thrombin, and not by other platelet agonists, in purified human platelets …
contraction and remodeling of the platelet actin cytoskeleton. In various other cell types,
AMP‐activated protein kinase (AMPK) controls the phosphorylation state of cytoskeletal
targets. Objective To determine whether AMPK is activated during platelet aggregation and
contributes to the control of cytoskeletal targets. Results We found that AMPK‐α1 was mainly
activated by thrombin, and not by other platelet agonists, in purified human platelets …