[HTML][HTML] Protein phosphatase 2A negatively regulates integrin αIIbβ3 signaling
FC Gushiken, V Patel, Y Liu, S Pradhan… - Journal of biological …, 2008 - ASBMB
Integrin α IIb β 3 activation is critical for platelet physiology and is controlled by signal
transduction through kinases and phosphatases. Compared with kinases, a role for
phosphatases in platelet integrin α IIb β 3 signaling is less understood. We report that the
catalytic subunit of protein phosphatase 2A (PP2Ac) associates constitutively with the
integrin α IIb β 3 in resting platelets and in human embryonal kidney 293 cells expressing α
IIb β 3. The membrane proximal KVGFFKR sequence within the cytoplasmic domain of …
transduction through kinases and phosphatases. Compared with kinases, a role for
phosphatases in platelet integrin α IIb β 3 signaling is less understood. We report that the
catalytic subunit of protein phosphatase 2A (PP2Ac) associates constitutively with the
integrin α IIb β 3 in resting platelets and in human embryonal kidney 293 cells expressing α
IIb β 3. The membrane proximal KVGFFKR sequence within the cytoplasmic domain of …