Clinical and radiologic disease in smokers with normal spirometry

EA Regan, DA Lynch, D Curran-Everett… - JAMA internal …, 2015 - jamanetwork.com
Importance Airflow obstruction on spirometry is universally used to define chronic obstructive
pulmonary disease (COPD), and current or former smokers without airflow obstruction may
assume that they are disease free. Objective To identify clinical and radiologic evidence of
smoking-related disease in a cohort of current and former smokers who did not meet
spirometric criteria for COPD, for whom we adopted the discarded label of Global Initiative
for Obstructive Lung Disease (GOLD) 0. Design, Setting, and Participants Individuals from …