Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products
Free radical research, 2013•Taylor & Francis
The advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs)
contribute to the development of diabetic complications and of other pathologies. The review
discusses the possibilities of counteracting the formation and stimulating the degradation of
these species by pharmaceuticals and natural compounds. The review discusses inhibitors
of ALE and AGE formation, cross-link breakers, ALE/AGE elimination by enzymes and
proteolytic systems, receptors for advanced glycation end products (RAGEs) and blockade …
contribute to the development of diabetic complications and of other pathologies. The review
discusses the possibilities of counteracting the formation and stimulating the degradation of
these species by pharmaceuticals and natural compounds. The review discusses inhibitors
of ALE and AGE formation, cross-link breakers, ALE/AGE elimination by enzymes and
proteolytic systems, receptors for advanced glycation end products (RAGEs) and blockade …
Abstract
The advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs) contribute to the development of diabetic complications and of other pathologies. The review discusses the possibilities of counteracting the formation and stimulating the degradation of these species by pharmaceuticals and natural compounds. The review discusses inhibitors of ALE and AGE formation, cross-link breakers, ALE/AGE elimination by enzymes and proteolytic systems, receptors for advanced glycation end products (RAGEs) and blockade of the ligand–RAGE axis.
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