Dietary glycotoxins exacerbate progression of experimental fatty liver disease
C Leung, CB Herath, Z Jia, M Goodwin, KY Mak… - Journal of …, 2014 - Elsevier
Background & Aims Advanced glycation end-products (AGEs) levels are high in western
diets and contribute to tissue injury via activation of RAGE (receptor for AGEs) and
generation of reactive oxygen species (ROS). Here, we determined if high dietary AGE
intake worsens progression of non-alcoholic fatty liver disease (NAFLD). Methods Male
Sprague Dawley rats were fed a methionine choline deficient (MCD) diet for 6 weeks before
6 weeks of a high AGE MCD diet through baking. They were compared with animals on …
diets and contribute to tissue injury via activation of RAGE (receptor for AGEs) and
generation of reactive oxygen species (ROS). Here, we determined if high dietary AGE
intake worsens progression of non-alcoholic fatty liver disease (NAFLD). Methods Male
Sprague Dawley rats were fed a methionine choline deficient (MCD) diet for 6 weeks before
6 weeks of a high AGE MCD diet through baking. They were compared with animals on …