Antigen-specific NK cell memory in rhesus macaques
Nature immunology, 2015•nature.com
Natural killer (NK) cells have traditionally been considered nonspecific components of
innate immunity, but recent studies have shown features of antigen-specific memory in
mouse NK cells. However, it has remained unclear whether this phenomenon also exists in
primates. We found that splenic and hepatic NK cells from SHIVSF162P3-infected and
SIVmac251-infected macaques specifically lysed Gag-and Env-pulsed dendritic cells in an
NKG2-dependent fashion, in contrast to NK cells from uninfected macaques. Moreover …
innate immunity, but recent studies have shown features of antigen-specific memory in
mouse NK cells. However, it has remained unclear whether this phenomenon also exists in
primates. We found that splenic and hepatic NK cells from SHIVSF162P3-infected and
SIVmac251-infected macaques specifically lysed Gag-and Env-pulsed dendritic cells in an
NKG2-dependent fashion, in contrast to NK cells from uninfected macaques. Moreover …
Abstract
Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from SHIVSF162P3-infected and SIVmac251-infected macaques specifically lysed Gag- and Env-pulsed dendritic cells in an NKG2-dependent fashion, in contrast to NK cells from uninfected macaques. Moreover, splenic and hepatic NK cells from Ad26-vaccinated macaques efficiently lysed antigen-matched but not antigen-mismatched targets 5 years after vaccination. These data demonstrate that robust, durable, antigen-specific NK cell memory can be induced in primates after both infection and vaccination, and this finding could be important for the development of vaccines against HIV-1 and other pathogens.
nature.com