[HTML][HTML] Loss of Hypermethylated in Cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through β-2 adrenergic receptor …

G Boulay, N Malaquin, I Loison, B Foveau… - Journal of Biological …, 2012 - ASBMB
The transcriptional repressor HIC1 (Hypermethylated in Cancer 1) is a tumor suppressor
gene inactivated in many human cancers including breast carcinomas. In this study, we
show that HIC1 is a direct transcriptional repressor of β-2 adrenergic receptor (ADRB2).
Through promoter luciferase activity, chromatin immunoprecipitation (ChIP) and sequential
ChIP experiments, we demonstrate that ADRB2 is a direct target gene of HIC1,
endogenously in WI-38 cells and following HIC1 re-expression in breast cancer cells …