The short and long telomere syndromes: paired paradigms for molecular medicine
SE Stanley, M Armanios - Current opinion in genetics & development, 2015 - Elsevier
SE Stanley, M Armanios
Current opinion in genetics & development, 2015•ElsevierRecent advances have defined a role for abnormally short telomeres in a broad spectrum of
genetic disorders. They include rare conditions such as dyskeratosis congenita as well
pulmonary fibrosis and emphysema. Now, there is new evidence that some familial cancers,
such as melanoma, are caused by mutations that lengthen telomeres. Here, we examine the
significance of these short and long telomere length extremes for understanding the
molecular basis of age-related disease and cancer.
genetic disorders. They include rare conditions such as dyskeratosis congenita as well
pulmonary fibrosis and emphysema. Now, there is new evidence that some familial cancers,
such as melanoma, are caused by mutations that lengthen telomeres. Here, we examine the
significance of these short and long telomere length extremes for understanding the
molecular basis of age-related disease and cancer.
Recent advances have defined a role for abnormally short telomeres in a broad spectrum of genetic disorders. They include rare conditions such as dyskeratosis congenita as well pulmonary fibrosis and emphysema. Now, there is new evidence that some familial cancers, such as melanoma, are caused by mutations that lengthen telomeres. Here, we examine the significance of these short and long telomere length extremes for understanding the molecular basis of age-related disease and cancer.
Elsevier