IL-6 and serum amyloid A synergy mediates angiotensin II–induced muscle wasting
L Zhang, J Du, Z Hu, G Han… - Journal of the …, 2009 - journals.lww.com
Animal studies suggest that increased levels of circulating angiotensin II (AngII) could
contribute to the loss of lean body mass in chronic kidney disease, but the mechanism by
which this occurs is unclear. Here, AngII infusion increased circulating IL-6 and its hepatic
production in wild-type mice, suggesting that AngII-induced inflammation may trigger muscle
loss. AngII infusion also stimulated the suppressor of cytokine signaling (SOCS3) in muscle,
which led to loss of insulin receptor substrate 1 (IRS-1), thereby impairing insulin/IGF-1 …
contribute to the loss of lean body mass in chronic kidney disease, but the mechanism by
which this occurs is unclear. Here, AngII infusion increased circulating IL-6 and its hepatic
production in wild-type mice, suggesting that AngII-induced inflammation may trigger muscle
loss. AngII infusion also stimulated the suppressor of cytokine signaling (SOCS3) in muscle,
which led to loss of insulin receptor substrate 1 (IRS-1), thereby impairing insulin/IGF-1 …