Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators
M Kitagawa - The journal of biochemistry, 2016 - academic.oup.com
M Kitagawa
The journal of biochemistry, 2016•academic.oup.comNotch signalling plays pivotal roles in development and homeostasis of all metazoan
species. Notch is a receptor molecule that directly translates information of cell–cell contact
to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor
that supports the activity of Notch. Here, the past and current studies of the interplay between
these factors are reviewed.
species. Notch is a receptor molecule that directly translates information of cell–cell contact
to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor
that supports the activity of Notch. Here, the past and current studies of the interplay between
these factors are reviewed.
Abstract
Notch signalling plays pivotal roles in development and homeostasis of all metazoan species. Notch is a receptor molecule that directly translates information of cell–cell contact to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor that supports the activity of Notch. Here, the past and current studies of the interplay between these factors are reviewed.
Oxford University Press