MicroRNA-494 reduces ATF3 expression and promotes AKI
YF Lan, HH Chen, PF Lai, CF Cheng… - Journal of the …, 2012 - journals.lww.com
MicroRNA-494 mediates apoptosis and necrosis in several types of cells, but its renal target
and potential role in AKI are unknown. Here, we found that microRNA-494 binds to the 3′
UTR of activating transcription factor 3 (ATF3) and decreases its transcription. In mice,
overexpression of microRNA-494 significantly attenuated the level of ATF3 and induced
inflammatory mediators, such as IL-6, monocyte chemotactic protein-1, and P-selectin, after
renal ischemia/reperfusion, exacerbating apoptosis and further decreasing renal function …
and potential role in AKI are unknown. Here, we found that microRNA-494 binds to the 3′
UTR of activating transcription factor 3 (ATF3) and decreases its transcription. In mice,
overexpression of microRNA-494 significantly attenuated the level of ATF3 and induced
inflammatory mediators, such as IL-6, monocyte chemotactic protein-1, and P-selectin, after
renal ischemia/reperfusion, exacerbating apoptosis and further decreasing renal function …